Hi Russell, Thanks for the information. I do have two questions/concerns, though: On Thu, Nov 19, 2009 at 8:09 PM, Russell McMahon wrote: > > Note that anything ending in ...coxib has been withdrawn for sale due > to large increases in heart related fatalities (and a $US1BN dollar > settlement). > According to wikipedia, some of the COX-2 inhibitors are still available in the US. It refers to only one, Vioxx (rofecoxib), as being withdrawn. see: http://en.wikipedia.org/wiki/Celecoxib > Paracetamol 1000 alone is about half as effective. > Note !!!! - FDA guidelines (based on an extensive investigation), > issued since this survey was completed, place Paracetamol 1000 above > the maximum safe single dose (due to excessive incidence of liver > damage when previously recommended levels were used.) > Do you mean a 1000mg dose of paracetamol? That's the standard maximum strength dose here in the US as an over-the-counter drug (two 500mg tablets). I was unable to find a statement saying that the FDA considered this beyond the max recommended dose. Instead, wikipedia once again says that 1000mg IS the maximum recommended dose to be taken at one time, and a total of 4000mg in 24 hours. Sean -- http://www.piclist.com PIC/SX FAQ & list archive View/change your membership options at http://mailman.mit.edu/mailman/listinfo/piclist