Just read an interesting blog post from Microsoft.
http://office.microsoft.com/en-us/help/HA102255591033.aspx

No 3 is my favorite and I've seen a small scale of similar incident
with 10s of emails from several continents. You do not need to
use Office (Outlook) to make this mistake.

Quote from the article.
*************************************************
"Replying-all to huge mailing lists.  Any email to a large alias
inevitably results in
someone (no doubt a proud Hootie CD owner) replying to everyone. The threads
are always the same. Something rather mundane or obscure is sent to thousan=
ds
of people. Then the fan mail starts pouring in:
"Why am I on this list?"
"Unsubscribe."
"Please also remove me!"
"Please stop replying to everyone =97 there are thousands of people on
this alias."
"Me too!"
"SERIOUSLY =97 STOP REPLYING ALL!"
"Why are you shouting?"
"We never talk anymore."

The most famous of these threads at Microsoft started on a mysterious
distribution list
called "Bedlam DL3." 25,000 employees, 15.5 million e-mails, 195 GB of
bandwidth,
busted network. T-shirts were printed to commemorate the event.
*************************************************

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