I can see a whole new wave of miracle-cures coming again from the colloidal-gold alternative healing communities. Regards/Roger, in Bangkok On 6/22/07, Russell McMahon wrote: > > GOLD-coated glass "nanoshells" can reveal the location of tumours and > then destroy them minutes later in a burst of heat. > > Using these particles to detect and destroy tumours could speed up > cancer treatment and reduce the use of potentially toxic drugs. It > could also make treatment cheaper, says Andre Gobin of Rice University > in Houston, Texas, who helped to create the particles. > > > Presently only works extremely close to body surface. > Work being done to extend depth. > > > http://www.newscientist.com/article/mg19426096.500?DCMP=NLC-nletter&nsref=mg19426096.500 > > > In 2003 Gobin's supervisor Jennifer West showed that gold-coated > silica nanospheres could destroy tumours in mice, while leaving normal > tissue intact. The blood vessels surrounding tumours are leakier than > those in healthy tissue, so spheres injected into the bloodstream tend > to accumulate at tumour sites. Illuminating the tumour with a > near-infrared laser then excites a "sea" of loose electrons around the > gold atoms via a process called plasmon resonance. This creates heat, > killing all the nearby cells. > > However, before this can happen doctors first have to make sure they > find all the tumour sites, which requires an MRI or CT scan. This > extra stage can mean multiple hospital visits and more drugs for the > patient. > > Now the team has shown how to tweak the size of the nanoshells so that > they also scatter some of the radiation. That means any cancer sites > will "light up" under low-intensity infrared, so they can then be > zapped with the laser. "We can use one single particle to accomplish > two tasks and neither feature is diminished greatly," says Gobin. > > To achieve this, the team had to carry out a delicate balancing act. > Smaller spheres convert more radiation to heat, which makes them > better at destroying tumours, but larger ones scatter more radiation, > which is vital for the imaging stage. Previously, the spheres were 120 > nanometres in diameter, which meant they only scattered 15 per cent of > the light shone on them, and converted the rest to heat. West's team > increased their size to 140 nanometres, causing them to convert 67 per > cent of the light to heat, and to scatter the remaining 33 per cent. > > The team injected the new particles into mice with colon carcinoma > tumours and used a technique called optical coherence tomography to > test their ability to act as an imaging agent. This involves shining > low-power near-infrared light onto the tissue and then measuring where > the scattered light bounces back. They found that the nanoparticles > caused tumour tissue to light up 56 per cent more strongly than > healthy tissue. > > The team then applied a higher-power infrared laser to each tumour > site for 3 minutes to heat the tissue. After a few weeks, they found > the tumours had been almost completely destroyed. Eighty per cent of > the mice treated survived for more than seven weeks, while all the > control mice, who did not receive the nanoshells, died after three > weeks. > > "Using one particle to detect and destroy tumours could cut treatment > length" > Since optical coherence tomography only penetrates up to 2 > millimetres, the imaging step will only be useful for locating tumours > near the surface, such as cervical, mouth and skin cancers, says > Gobin. However, the team plans to modify the nanoshells so that they > work with more deeply penetrating radiation, such as X-rays. > Houston-based Nanospectra Biosciences, which West co-founded, will > begin trials of the spheres in humans in the next two months. > > -- > http://www.piclist.com PIC/SX FAQ & list archive > View/change your membership options at > http://mailman.mit.edu/mailman/listinfo/piclist > -- http://www.piclist.com PIC/SX FAQ & list archive View/change your membership options at http://mailman.mit.edu/mailman/listinfo/piclist