barryc wrote:
> If I attach a +2.5V to vref+ and -2.5 refrence to vref- and allow my
> Vin to range naturally, it doesn't seem to work right.

-2.5V on Vref- probably caused permanet damage to the PIC.  See data sheet.

> Can the ADC handle the negative voltages directly,

RTFM!

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