> An apparently minor change can have results out of all
> proportion. Consider
> a gene to be a sub-program.The subprogram typically results
> in the creation
> of a machine - a protein, via some intermediate machines.

The example which springs to mind is that of Sickle Cell Anaemia - caused by the substitution of *a single base pair* somewhere in a gene to do with haemoglobin production.

From 'being normal' to having a life threatening disease thanks to one base in 3 billion being 'wrong'. Ouch.

Chris.

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