> At 11:27 PM 10/18/99 -0400, Sean wrote: > >How can a non-inverting follower work without at least a negative supply? I > >interpreted "negative reference" to mean "negative supply" in this case. > > > >If we could use an inverting buffer, THEN it wouldn't need a negative > >supply. However, good luck finding a high enough Rin, > > As far as I know, you never need to have bipolar supplies. You just need a > Vss and a Vdd and a common point in between, typically at the midpoint. > > The common voltage becomes the signal ground. The full Vcc becomes the > 'plus' voltage. The power supply ground becomes the 'minus' voltage. >From what I can tell, you're suggesting to basically connect one end of the electrode to 2.5V. I'd then be running current through the electrode and I'm not sure that's a good thing... I found an interesting part in the Burr Brown INA116 differential amplifier. Not too cheap but seems ideal for this. Looks really easy to use too. Just get a 2.5V reference, plug in a resistor for gain and I'm set. My concern would be ESD with this device though. Any way to help control ESD across really sensitive inputs? Unless there's a convincing argument otherwise, I think I'm going to go with this part instead of DIYing a differential amp with lots of external parts. The LMC660 looks like a good cheap part. I'll probably use that for non-pH inputs. Thanks for everyone that replied to help me get this input into a PIC. Chris