Personally, I have an older 16bit windows version of
OrCad.  Never had much of a problem with it (did hang on my old 486 once
and while), but here at work we use ViewLogic for schematic capture and
Cadnetix (with the Cooper-Chan autoroute engine).

                Viewlogic has lousy support, but one nice thing is that
the files are ascii, and so I can go in with my editor and do global
search and replace, or do grep on a group of files to find signals.