I agree with Scott's elaboration on my caution about the ambient temperature effects on the resistors of the circuit. I used the resistors as an example but the op-amp may have as much error contribution through variation of input offset voltages with temperature. For high accuracy, all components need to be selected for temperature stability. Also, Scott's suggestion to sample the power supply voltage in addition to the signal is a good one if you have an extra ADC. Another alternative is to use a band gap reference with good temperature stability to generate the subtraction voltage. Mark A. Corio Rochester MicroSystems, Inc. 200 Buell Road, Suite 9 Rochester, NY 14624 Tel: (716) 328-5850 Fax: (716) 328-1144 e-mail: Mcorio@aol.com ***** Designing Electronics For Research & Industry *****